To　take　the　proper　seismic　isolation　measures　for　the　fixed　piers　of　multi-span　concrete　continuous　girder　bridge　is　an　effective　way　to　improve　the　piers　subjected　to　the　action　of　seismic　force.　In　this　paper,　a　six-span　concrete　continuous　girder　bridge　was　cited　as　an　example　and　by　means　of　the　finite　element　software　ANSYS,　two　kinds　of　the　seismic　isolation　systems　of　the　friction　pendulum　bearings　and　seismic　mitigation　spherical　bearings　respectively　arranged　on　the　intermediate　piers　of　the　bridge　were　calculated　and　analyzed　and　the　laws　of　influences　of　the　two　kinds　of　the　systems　on　the　seismic　responses　of　the　bridge　were　studied.　The　results　of　the　study　indicate　that　the　two　kinds　of　the　systems　can　effectively　reduce　the　internal　forces　and　displacement　of　the　piers　in　the　longitudinal　direction　of　the　bridge.　In　comparison　with　the　seismic　resistant　system,　the　force　conditions　of　the　seismic　isolation　system　are　more　reasonable　and　in　consideration　of　the　vertical　bearing　capacity　and　resilient　stiffness　of　the　bearings,　the　friction　pendulum　bearings　have　obvious　advantage　and　it　is　therefore　proposed　that　the　pendulum　bearings　should　be　selected　for　such　type　of　the　bridges　where　the　seismic　isolation　measures　are　required　to　be　taken.