In　order　to　improve　the　value　of　virtual　surgery　simulation,　convenient　medical　research　blood　vessels,　piping,　structure　and　geometry　similarities　based　on　pipes,　the　many-branched　trees　of　parametric　three-dimensional　modeling　idea　to　vascular　piping　three-dimensional　one　were　applied.　Based　on　the　extraction　of　liver　portal　vein　three-dimensional　skeleton,　a　method　of　reconstruction　of　liver　vascular　model　in　B　spline　curve　was　studied.　Vascular　three-dimensional　shape　was　defined　by　generalized　cylinder,　the　B-spline　curve　fitting　the　three-dimensional　spatial　skeleton,　and　then　calculating　fitted　curve　of　several　feature　points　of　the　Frenet　frame,　soluting　the　tangent　of　feature　points,　then　drawing　the　feature　point　as　the　center　of　the　circle　and　perpendicular　to　the　tangent　of　transverse　circle,　finally　according　to　the　cross-sectional　contour　point　on　the　circle　surface　reconstruction　to　draw　the　vascular　based　on　the　generalized　cylinder　model.　The　result　shows　that　using　this　method　the　vascular　pipeline　model　can　be　easily　reconstructed,　meantime　the　model　can　be　manipulated,　monitored　and　edited　in　real　time.　Its　advantage　of　direct　and　convenience　has　certain　guiding　significance　for　the　frequent　interactive　virtual　surgery.　©,　2014,　Chinese　Association　for　System　Simulation.　All　right　reserved.