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author：

Zheng, Q. (Zheng, Q..) [1] | Lin, T. (Lin, T..) [2] | Wu, H. (Wu, H..) [3] | Guo, L. (Guo, L..) [4] | Ye, P. (Ye, P..) [5] | Hao, Y. (Hao, Y..) [6] | Guo, Q. (Guo, Q..) [7] | Jiang, J. (Jiang, J..) [8] | Fu, F. (Fu, F..) [9] | Chen, G. (Chen, G..) [10]

Indexed by：

Scopus

Abstract：

A　novel　pH-sensitive　controlled　release　system　is　proposed　by　using　mussel-inspired　polydopamine　(PDA)　coated　mesoporous　silica　nanoparticles　(MSNs)　as　nanocarriers.　MSNs　with　a　large　pore　diameter　are　synthesized　by　using　1,3,5-trimethylbenzene　as　a　pore-expanding　agent　and　are　modified　with　a　PDA　coating　by　virtue　of　oxidative　self-polymerization　of　dopamine　in　neutral　pH.　PDA　coated　MSNs　are　characterized　by　FTIR,　TEM,　N2　adsorption　and　XPS　techniques.　The　PDA　coating　can　work　as　pH-sensitive　gatekeepers　to　control　the　release　of　drug　molecules　from　MSNs　in　response　to　the　pH-stimulus.　Doxorubicin　(DOX,　an　anticancer　drug)　can　be　released　in　the　acid　media　and　blocked　in　the　neutral　media.　©　2014　Elsevier　B.V.

Keyword：

Controlled release; Drug delivery; Mesoporous silica nanoparticles; Polydopamine

Community：

  • [ 1 ] [Zheng, Q.]Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, Fujian Prov. Key Lab. of Anal. and Detection Technology for Food Safety and Department of Chemistry, Fuzhou University, Fuzhou 350108, China
  • [ 2 ] [Lin, T.]Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, Fujian Prov. Key Lab. of Anal. and Detection Technology for Food Safety and Department of Chemistry, Fuzhou University, Fuzhou 350108, China
  • [ 3 ] [Wu, H.]Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, Fujian Prov. Key Lab. of Anal. and Detection Technology for Food Safety and Department of Chemistry, Fuzhou University, Fuzhou 350108, China
  • [ 4 ] [Guo, L.]Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, Fujian Prov. Key Lab. of Anal. and Detection Technology for Food Safety and Department of Chemistry, Fuzhou University, Fuzhou 350108, China
  • [ 5 ] [Ye, P.]Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, Fujian Prov. Key Lab. of Anal. and Detection Technology for Food Safety and Department of Chemistry, Fuzhou University, Fuzhou 350108, China
  • [ 6 ] [Hao, Y.]Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, Fujian Prov. Key Lab. of Anal. and Detection Technology for Food Safety and Department of Chemistry, Fuzhou University, Fuzhou 350108, China
  • [ 7 ] [Guo, Q.]Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, Fujian Prov. Key Lab. of Anal. and Detection Technology for Food Safety and Department of Chemistry, Fuzhou University, Fuzhou 350108, China
  • [ 8 ] [Jiang, J.]Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, Fujian Prov. Key Lab. of Anal. and Detection Technology for Food Safety and Department of Chemistry, Fuzhou University, Fuzhou 350108, China
  • [ 9 ] [Fu, F.]Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, Fujian Prov. Key Lab. of Anal. and Detection Technology for Food Safety and Department of Chemistry, Fuzhou University, Fuzhou 350108, China
  • [ 10 ] [Chen, G.]Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, Fujian Prov. Key Lab. of Anal. and Detection Technology for Food Safety and Department of Chemistry, Fuzhou University, Fuzhou 350108, China

Reprint 's Address：

  • [Guo, L.]Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, Fujian Prov. Key Lab. of Anal. and Detection Technology for Food Safety and Department of Chemistry, Fuzhou University, Fuzhou 350108, China

Email：


lqguo@fzu.edu.cn
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Source ：

International Journal of Pharmaceutics

ISSN： 0378-5173

Year： 2014

Issue： 1

Volume： 463

Page： 22-26

3 . 6 5

JCR@2014

5 . 3 0 0

JCR@2023

ESI HC Threshold：205

JCR Journal Grade：1

CAS Journal Grade：2

Cited Count：

WoS CC Cited Count： 0

SCOPUS Cited Count： 166

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 2

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