We　prepare　Er3+/Yb3+　co-doped　oxyfluoride　glass　ceramic　samples　by　high　temperature　calcination　method　(41.2SiO2-29.4Al2O3　-　17.6Na2CO3-11.8LaF3　-　0.5ErF3-2.5　YbF3),　and　also　fabricate　transparent　microspheres　each　with　a　handle.　We　propose　a　new　method　of　studying　the　luminescent　properties　of　Er3+/Yb3+　co-doped　oxyfluoride　glass　ceramic　with　the　tapered　fiber-microsphere　coupling　system.　The　method　has　characteristics　such　as　low　excitation　optical　power,　easy　preparation　and　testing.　We　couple　the　976　nm　laser　into　the　microspheres　with　the　coupler　of　optical　tapered　fiber,　then　the　fluorescence　and　laser　are　connected　to　spectrum　analyzer　with　the　optical　tapered　fiber.　The　strong　up-conversion　fluorescences　at　522,　545　and　657　nm　are　obtained,　and　the　laser　oscillation　spectra　generated　by　Er3+　ions　at　1562　nm　are　also　measured.　The　up-conversion　luminescence　mechanism　of　Er3+,　the　mechanism　of　high　luminescence　efficiency　in　Er3+/Yb3+　co-doped　oxyfluoride　glass　ceramic　microsphere,　and　the　mechanism　of　higher　laser　oscillation　threshold　in　the　oxyfluoride　glass　ceramic　microsphere　than　in　the　SiO2　matrix　microsphere　are　all　analyzed.　©　2014　Chinese　Physical　Society.