An　efficient　and　practical　approach　to　α-trifluoromethylthio-substituted　ketones　was　developed.　The　trifluoromethylthiolation　of　(bpy)Cu(SCF3)　(bpy　=　2,2′-bipyridyl)　with　various　α-bromo　ketones　afforded　the　desired　α-trifluoromethylthio-substituted　ketones　in　good　yields.　The　reaction　tolerates　more　functionally　than　previously　reported　methods　and　demonstrates　efficient　scalability　and　practicality.　An　improved　protocol　for　the　copper-mediated　trifluoromethylthiolation　of　α-bromo　ketones　by　using　(bpy)Cu(SCF3)　(bpy　=　2,2′-bipyridyl)　to　afford　the　corresponding　α-trifluoromethylthio-substituted　ketones　in　good　to　excellent　yields　is　presented.　The　procedure　tolerates　electron-withdrawing　and　electron-donating　groups　on　the　aromatic　rings.　Copyright　©　2014　WILEY-VCH　Verlag　GmbH　&　Co.　KGaA,　Weinheim.