Dicitrinone D, an antimitotic polyketide isolated from the marine-derived fungus Penicillium citrinum - Details

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Abstract：

Dicitrinone　D　is　a　novel　polyketide　isolated　from　a　marine-derived　fungus　Penicillium　citrinum.　In　this　study,　we　described　the　isolation,　structure　elucidation　and　antitumor　mechanism　of　this　compound.　Cell　proliferation　assay　showed　that　dicitrinone　D　was　safe　for　normal　cells,　but　effectively　inhibited　the　growth　of　multiple　tumor　cells,　especially　SPC-A1　cells.　Cell　cycle　and　immunofluorescence　analysis　suggested　that　dicitrinone　D　had　cellular　effects　similar　to　other　microtubule-targeting　agents.　Polymerization　assay,　electron　microscopy　and　time-lapsed　video　microscopy　assay　demonstrated　dicitrinone　D　was　a　microtubule-destabilizing　agent.　Finally,　the　docking　analysis　predicted　that　dicitrinone　D　may　bind　to　vinblastine　binding　site　on　tubulin.　©　2017

Keyword：

Conformation analysis; Marine-derived fungus; Microtubule-destabilizing; Polyketide; Structure elucidation

Community：

[ 1 ] [Chen, L.]Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou, 350002, China
[ 2 ] [Zhao, Y.-Y.]Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou, 350002, China
[ 3 ] [Lan, R.-F.]Department of Cell Biology and Medical Genetics, School of Medicine, Shenzhen University, Shenzhen, 518060, China
[ 4 ] [Du, L.]Institute for Natural Products Applications and Research Technologies, Department of Chemistry and Biochemistry, University of Oklahoma, Norman, 73019-5251, United States
[ 5 ] [Wang, B.-S.]Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou, 350002, China
[ 6 ] [Zhou, T.]Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou, 350002, China
[ 7 ] [Li, Y.-P.]Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou, 350002, China
[ 8 ] [Zhang, Q.-Q.]Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou, 350002, China
[ 9 ] [Zhang, Q.-Q.]Institute of Biomedical Engineering, Chinese Academy of Medical Science, Peking Union Medical College, Tianjin, 300192, China
[ 10 ] [Ying, M.-G.]Fujian Provincial Key Laboratory of Tumor Biotherapy, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou, 350014, China
[ 11 ] [Zheng, Q.-H.]Fujian Provincial Key Laboratory of Tumor Biotherapy, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou, 350014, China
[ 12 ] [Liu, Q.-Y.]Fujian Provincial Key Laboratory of Tumor Biotherapy, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou, 350014, China
[ 13 ] [Liu, Q.-Y.]Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, 77030, United States

Reprint 's Address：

[Liu, Q.-Y.]Institute of Biomedical and Pharmaceutical Technology, Fuzhou UniversityChina

Email：

liuqinyingbio@163.com

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Source ：

Tetrahedron

ISSN： 0040-4020

Year： 2017

Issue： 40

Volume： 73

Page： 5900-5911

2 . 3 7 7

JCR@2017

2 . 1 0 0

JCR@2023

ESI HC Threshold：226

JCR Journal Grade：2

CAS Journal Grade：3

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SCOPUS Cited Count：

ESI Highly Cited Papers on the List： 0 Unfold All

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Chinese Cited Count：

30 Days PV： 1

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