A　copper(I)-catalyzed　interrupted　click　reaction　in　the　presence　of　trifluoroacetic　anhydride　has　been　developed,　wherein　an　N-trifluoroacetyl　group　is　used　to　accelerate　the　ring-opening　of　the　putative　5-copper(I)　triazolide　intermediate.　Under　the　optimized　reaction　conditions,　a　broad　range　of　azides　and　alkynes　were　found　to　participate　in　this　transformation,　thus　affording　3-trifluoromethyl-substituted　1,2,4-triazinones　in　moderate　to　excellent　yields.　The　reaction　has　proven　to　be　compatible　with　a　variety　of　electron-withdrawing　and　electron–donating　groups,　halogens,　and　nitrogen-　and　sulfur-containing　heterocycles,　as　well　as　pharmaceutically　relevant　molecules.　©　2017　Wiley-VCH　Verlag　GmbH　&　Co.　KGaA,　Weinheim