The　research　of　MSN-based　controlled　drug　release　systems　has　been　one　of　the　current　common　interests　of　biomedicine　and　material　science.　Recently,　biomolecules　were　extensively　used　to　modify　the　mesoporous　silica　nanoparticles　owning　to　their　biocompatible,　biodegradable,　nontoxic　and　targeting　properties.　Herein,　the　research　of　MSN-based　drug　delivery　systems,　which　were　capped　by　various　biomolecules　was　reviewed.　It　mainly　was　focused　on　the　linked　and　responsive　mechanisms　between　the　biomolecules　and　the　MSN.　Finally,　the　difficulties　in　current　research　and　the　application　prospect　were　discussed,　which　afford　references　and　ideas　for　the　future　study　in　controlled　drug　release.　©　2017,　Chongqing　Functional　Materials　Periodical　Press　Co.　Ltd.　All　right　reserved.