In　this　study,　we　examined　the　effect　of　ethyl　cellulose　as　organogel　on　animal　nutrition　physiological　function　by　the　rat　feeding　test,　including　the　high　risk　factor　of　cardiovascular　disease.　The　results　showed　that　rat　body　weight　of　experimental　groups　was　lower　than　the　control　group,　and　the　high　dose　group　was　the　lowest.　The　data　also　showed　the　indexes　of　free　fatty　acid,　uric　acid　were　significantly　lower　than　that　of　the　control　group.　Compared　with　other　groups,　high　does　of　ethyl　cellulose　increased　the　level　of　albumin,　globulin,　total　protein　and　leptin　of　rat.　In　addition,　the　level　of　high　density　lipoprotein,　AAI　of　anti　atherogenic　were　higher　than　that　of　control　group　(P＜0.05);　both　AI　of　atherogenic　index　and　lipase　activity　were　significantly　lower　than　control　group　(P＞0.05).　On　the　other　hand,　high　dose　group　rats　have　the　higher　level　of　serum　glucose,　total　cholesterol,　triglyceride,　low　density　lipoprotein　and　the　ratio　of　high　density　lipoprotein　cholesterol　and　low　density　lipoprotein　(HDL/LDL　value)　than　other　groups.　With　feed　of　ethyl　cellulose　shortenings,　there　was　not　adverse　effects　on　rats.　©　2017,　Editorial　Office　of　Journal　of　CIFST.　All　right　reserved.