Dimethyl　carbonate　is　an　environmentally　benign　and　biodegradable　chemical.　Based　on　integration　of　reactive　distillation　and　pressure-swing　distillation　technologies,　a　novel　process　for　synthesis　of　dimethyl　carbonate　through　transesterification　with　propylene　carbonate　and　methanol　has　been　developed　by　Huang　et　al.　In　this　work,　the　optimization　of　this　process　was　performed　by　minimizing　the　total　TAC.　The　results　show　that　the　optimal　design　flowsheet　can　save　energy　consumption　by　18.6%　with　the　propylene　carbonate　conversion　of　99.9%.　Then,　an　effective　plant-wide　control　structure　for　the　process　was　developed.　Dynamic　simulation　results　demonstrate　that　the　temperature/flow　rate　cascade　control　plus　with　simple　temperature　control　can　keep　not　only　product　purity　but　also　the　conversion　of　the　reactant　at　their　desired　values　in　the　face　of　the　disturbance　in　reactant　feed　flow　rate　and　feed　composition.　©　2017　Elsevier　B.V.