The　solubility　of　cefpiramide　in　five　pure　solvents　(water,　ethanol,　1-propanol,　2-propanol,　and　1-butanol)　and　two　binary　solvent　systems　(water + ethanol　or　water + 2-propanol)　was　measured　by　a　steady-state　method,　from　278.2　to　303.2 K,　under　atmospheric　pressure.　The　initial　mole　fraction　of　alcohol　(ethanol　or　2-propanol)　in　the　binary　systems　ranged　from　0　to　1.　It　is　found　that　the　solubility　increases　with　increasing　temperature　in　the　experimental　range　and　shows　a　quasi-S-shaped　curve　with　the　increase　of　the　initial　mole　fraction　of　alcohol.　The　modified　Apelblat　equation　was　used　to　simulate　the　solubility　data,　and　gives　a　maximum　mean　relative　deviation　(MRD)　of　0.47%　for　the　single　solvent　systems,　and　a　maximum　MRD　of　1.03　and　1.15%　for　the　ethanol + water　and　2-propanol + water　systems,　respectively.　The　combined　model　of　the　Jouyban–Acree　and　modified　Apelblat　equations,　both　temperature-dependent　and　solvent-composition-dependent,　was　simplified　to　correlate　the　solubility　data　of　binary　solvent　mixtures　in　the　initial　mole　fraction　range　of　alcohol　from　0　to　0.9,　and　gives　a　MRD　of　9.83　and　6.49%　for　the　ethanol　+water　and　2-propanol + water　systems,　respectively.　The　dissolution　thermodynamic　properties　in　the　pure　solvents　and　two　binary　mixtures　were　calculated　based　on　the　van’t　Hoff　equation.　The　calculation　results　indicate　that　the　dissolution　process　of　cefpiramide　is　endothermic　in　the　pure　solvents,　and　entropically　driven　in　the　four　alcohols　but　not　in　water.　The　dissolution　process　is　endothermic　in　the　two　binary　mixtures.　©　2017,　Springer　Science+Business　Media,　LLC.