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author:

Lv, S. (Lv, S..) [1] | Li, Y. (Li, Y..) [2] | Zhang, K. (Zhang, K..) [3] | Lin, Z. (Lin, Z..) [4] | Tang, D. (Tang, D..) [5]

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Scopus

Abstract:

A class of 0-dimensional/2-dimensional (0D/2D) nanoheterostructures based on carbon quantum dots (CQDs) and graphitic carbon nitride (g-C 3 N 4 ) was designed as the signal-generation tags for the sensitive photoelectrochemical (PEC) immunoassay of prostate-specific antigen (PSA) coupling with the copper nanoclusters (CuNCs). Combination of CQDs with g-C 3 N 4 promoted the photoexcited electron/hole separation and largely increased the photocurrents of the nanoheterostructures. Initially, a sandwich-type immunoreaction was carried out on monoclonal anti-PSA antibody-coated microplate by using PSA aptamer linked with CuNCs as the tracer. Accompanying the immunocomplex, the carried CuNCs were dissolved under acidic conditions. The as-released copper ions from the CuNCs could be captured onto the CQDs/g-C 3 N 4 nanoheterostructures via the amino-group on the CQD surface as well as the -NH x (x = 1, 2, 3) of g-C 3 N 4 nanosheets. The strong coordination of the Lewis basic sites on the CQDs/g-C 3 N 4 with Cu 2+ decreased the photocurrent of the nanoheterostructures. Under optimal conditions, CQDs/g-C 3 N 4 nanoheterostructures displayed good photocurrent responses for the detection of PSA within the dynamic linear range of 0.02-100 ng mL -1 and a limit of detection (LOD) of 5.0 pg mL -1 . This method was also evaluated for quantitative screening of human PSA serum specimens by using the referenced electrochemiluminescent enzyme-linked immunoassay (ECL-ELIA) and gave good matched results between two methods. Additionally, this system was beneficial to explore the charge-separation and photoinduced electron transfer mechanism in the photoelectrochemical sensing protocols. © 2017 American Chemical Society.

Keyword:

carbon quantum dots; copper nanoclusters; graphitic carbon nitride; nanoheterostructures; photoelectrochemical immunoassay

Community:

  • [ 1 ] [Lv, S.]Key Laboratory of Analytical Science of Food Safety and Biology, MOE and Fujian Province, State Key Laboratory of Photocatalysis on Energy and Environment, Department of Chemistry, Fuzhou University, Fuzhou, 35011168, China
  • [ 2 ] [Li, Y.]Key Laboratory of Analytical Science of Food Safety and Biology, MOE and Fujian Province, State Key Laboratory of Photocatalysis on Energy and Environment, Department of Chemistry, Fuzhou University, Fuzhou, 35011168, China
  • [ 3 ] [Zhang, K.]Key Laboratory of Analytical Science of Food Safety and Biology, MOE and Fujian Province, State Key Laboratory of Photocatalysis on Energy and Environment, Department of Chemistry, Fuzhou University, Fuzhou, 35011168, China
  • [ 4 ] [Lin, Z.]Key Laboratory of Analytical Science of Food Safety and Biology, MOE and Fujian Province, State Key Laboratory of Photocatalysis on Energy and Environment, Department of Chemistry, Fuzhou University, Fuzhou, 35011168, China
  • [ 5 ] [Tang, D.]Key Laboratory of Analytical Science of Food Safety and Biology, MOE and Fujian Province, State Key Laboratory of Photocatalysis on Energy and Environment, Department of Chemistry, Fuzhou University, Fuzhou, 35011168, China

Reprint 's Address:

  • [Li, Y.]Key Laboratory of Analytical Science of Food Safety and Biology, MOE and Fujian Province, State Key Laboratory of Photocatalysis on Energy and Environment, Department of Chemistry, Fuzhou UniversityChina

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Source :

ACS Applied Materials and Interfaces

ISSN: 1944-8244

Year: 2017

Issue: 44

Volume: 9

Page: 38336-38343

8 . 0 9 7

JCR@2017

8 . 5 0 0

JCR@2023

ESI HC Threshold:306

JCR Journal Grade:1

CAS Journal Grade:2

Cited Count:

WoS CC Cited Count:

SCOPUS Cited Count: 143

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 3

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