Click-Conjugation of Nanogold-Functionalized PAMAM Dendrimer: Toward a Novel Electrochemical Detection Platform - Details

author：

Tang, Y. (Tang, Y..) ^[1] | Zhang, J. (Zhang, J..) ^[2] | Tang, D. (Tang, D..) ^[3] | Teng, L. (Teng, L..) ^[4] | Lv, J. (Lv, J..) ^[5]

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Scopus

Abstract：

This　work　reports　a　new　electrochemical　monitoring　platform　for　sensitive　detection　of　Cu2+　coupling　click　chemistry　with　nanogold-functionalized　PAMAM　dendrimer　(AuNP-PAMAM).　The　system　involved　an　alkyne-modified　carbon　electrode　and　an　azide-functionalized　AuNP-PAMAM.　Initially,　the　added　Cu2+　was　reduced　to　Cu+　by　the　ascorbate,　and　then　the　azide-modified　AuNP-PAMAM　was　covalently　conjugated　to　the　electrode　via　Cu+-catalyzed　azide-alkyne　click　reaction.　The　carried　AuNPs　accompanying　PAMAM　dendrimer　could　be　directly　monitored　by　stripping　voltammetry　after　acidic　pretreatment.　By　introduction　of　high-loading　PAMAM　dendrimer　with　gold　nanoparticles,　as　low　as　2.8pM　Cu2+　(ppt)　could　be　detected,　which　was　125-fold　lower　than　that　of　gold　nanoparticle-based　labeling　strategy.　The　method　exhibited　high　specificity　toward　target　Cu2+　against　other　potentially　interfering　ions,　and　was　applicable　for　monitoring　Cu2+　in　drinking　water　with　satisfactory　results.　©　2015　WILEY-VCH　Verlag　GmbH　&　Co.　KGaA,　Weinheim.

Keyword：

Click chemistry; Copper(II) ion; Electrochemical sensor; Nanogold-functionalized PAMAM dendrimer; Stripping voltammetry

Community：

[ 1 ] [Tang, Y.]Chongqing Key Laboratory of Environmental Materials and Remediation Technologies, Chongqing University of Arts and Sciences, Chongqing, 402160, China
[ 2 ] [Zhang, J.]Chongqing Key Laboratory of Environmental Materials and Remediation Technologies, Chongqing University of Arts and Sciences, Chongqing, 402160, China
[ 3 ] [Tang, D.]Chongqing Key Laboratory of Environmental Materials and Remediation Technologies, Chongqing University of Arts and Sciences, Chongqing, 402160, China
[ 4 ] [Teng, L.]Chongqing Key Laboratory of Environmental Materials and Remediation Technologies, Chongqing University of Arts and Sciences, Chongqing, 402160, China
[ 5 ] [Lv, J.]Chongqing Key Laboratory of Environmental Materials and Remediation Technologies, Chongqing University of Arts and Sciences, Chongqing, 402160, China
[ 6 ] [Tang, D.]Chongqing Key Laboratory of Environmental Materials and Remediation Technologies, Chongqing University of Arts and Sciences, Chongqing, 402160, China
[ 7 ] [Tang, D.]Institute of Nanomedicine and Nanobiosensing, Department of Chemistry, Fuzhou University, Fuzhou, 350108, China

Reprint 's Address：

[Tang, D.]Chongqing Key Laboratory of Environmental Materials and Remediation Technologies, Chongqing University of Arts and SciencesChina

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Source ：

Electroanalysis

ISSN： 1040-0397

Year： 2015

Issue： 10

Volume： 27

Page： 2280-2285

2 . 4 7 1

JCR@2015

2 . 7 0 0

JCR@2023

ESI HC Threshold：265

JCR Journal Grade：2

CAS Journal Grade：3

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count： 8

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 1

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