The　polyvinyl　alcohol(PVA)/chitosan(CS)　composite　nanofiber　was　fabricated　by　electrospinning,　and　the　drug　release　characteristic　of　PVA/CS　composite　nanofiber　wrapped　with　amoxicillin　was　observed.　The　influences　of　material　formulation,　electrospinning　voltage,　collection　distance　and　drug　content　on　morphology　of　PVA/CS　composite　nanofibers　were　studied　by　SEM.　The　drug　release　rate　of　drug　carrier　PVA/CS　composite　nanofiber　was　analyzed　through　UV-visible　spectrophotometer.　The　results　show　that,　with　the　increasing　of　electrospinning　voltage　and　collection　distance,　the　decreasing　of　drug　content,　the　diameter　of　PVA/CS　composite　nanofiber　decreases　and　its　distribution　uniformity　increases.　Moreover,　the　drug　release　rate　of　drug　carrier　PVA/CS　composite　nanofiber　decreases　with　the　increasing　of　drug　content　and　release　time.　©,　2015,　Chengdu　University　of　Science　and　Technology.　All　right　reserved.