Study on the fragmentation patterns of heparan sulfate disaccharides by ESI-MS - Details

author：

Lin, J.-H. (Lin, J.-H..) ^[1] | Zhang, J.-W. (Zhang, J.-W..) ^[2] | Zhang, H.-F. (Zhang, H.-F..) ^[3] | Gao, J.-P. (Gao, J.-P..) ^[4] | Wei, Z. (Wei, Z..) ^[5]

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Scopus PKU CSCD

Abstract：

The　structure　of　heparan　sulfate　determines　its　interaction　with　proteins,　therefore　the　analysis　of　heparan　sulfate　can　help　further　clarify　structure　and　function　relationships.　The　characteristic　fragmentation　pattern　of　twelve　heparan　sulfate　disaccharide　was　discussed　by　electrospray　ionization-ion　trap　mass　spectrometry　(ESI-MSn)　in　negative　mode.　The　results　show　that　the　position　and　quantity　of　sulfate　groups　in　disaccharide　determine　its　stability　in　MS,　moreover,　C-2sulfate　and　C-6　sulfate　in　disaccharide　are　more　stable　than　N-sulfate.　MS2　revealed　that　the　disaccharide　isomers　have　a　characteristic　fragment　pattern.　The　results　may　contribute　to　identify　the　disaccharides　isomer　of　heparan　sulfate,　which　can　provide　theoretical　knowleage　to　identify　the　structural　of　heparan　sulfate.　©,　2015,　Chinese　Society　for　Mass　Spectrometry.　All　right　reserved.

Keyword：

Electrospray ionization-ion trap-time flight mass spectrometry; Fragmentation patterns; Heparan sulfate disaccharides; Structure

Community：

[ 1 ] [Lin, J.-H.]Institute of Glycobiochemistry, Fuzhou University, Fuzhou, 350002, China
[ 2 ] [Zhang, J.-W.]Institute of Glycobiochemistry, Fuzhou University, Fuzhou, 350002, China
[ 3 ] [Zhang, H.-F.]Institute of Glycobiochemistry, Fuzhou University, Fuzhou, 350002, China
[ 4 ] [Gao, J.-P.]Institute of Glycobiochemistry, Fuzhou University, Fuzhou, 350002, China
[ 5 ] [Wei, Z.]Institute of Glycobiochemistry, Fuzhou University, Fuzhou, 350002, China

Reprint 's Address：

[Wei, Z.]Institute of Glycobiochemistry, Fuzhou UniversityChina

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Source ：

Journal of Chinese Mass Spectrometry Society

ISSN： 1004-2997

Year： 2015

Issue： 2

Volume： 36

Page： 111-119

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count： 2

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 2

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