Novel　metal-organic　frameworks　(MOFs)　based　solid　catalysts　have　been　synthesized　by　encapsulating　Hemin　into　the　HKUST-1　MOF　materials.　These　have　been　first　applied　in　the　chemiluminescence　field　with　outstanding　performance.　The　functionalized　MOFs　not　only　maintain　an　excellent　catalytic　activity　inheriting　from　Hemin　but　also　can　be　cyclically　utilized　as　solid　mimic　peroxidases　in　the　neutral　condition.　The　synthesized　Hemin@HKUST-1　composites　have　been　used　to　develop　practical　sensors　for　H2O2　and　glucose　with　wide　response　ranges　and　low　detection　limits.　It　was　envisioned　that　catalyst-functionalized　MOFs　for　chemiluminescence　sensing　would　have　promising　applications　in　green,　selective,　and　sensitive　detection　of　target　analytes　in　the　future.　©　2015　American　Chemical　Society.