The　preparation　of　β-In2S3　nanomaterial　was　carried　out　by　reacting　In　(NO3)　3　with　thioacetamide　through　hydrothermal　process　at　120℃　for　12　h.　The　size　and　morphology　of　In2S3　were　characterized　by　the　scanning　electron　microscope　(SEM),　transmission　electron　microscopy　(TEM)　and　X-ray　diffraction　(XRD)　while　the　degradation　efficiency　was　evaluated　by　the　photocatalytic　degradation　of　oxytetracycline　under　natural　sunlight.　The　results　revealed　that　β-In2S3　nanoparticles　are　made　up　of　nanosheets　with　a　length　of　15-30　nm　and　with　high　efficient　catalytic　performance,　in　which　more　than　98%　of　the　initial　oxytetracycline　(30　mg·L-1)　was　degraded　in　4　h.　Furthermore,　the　prepared　β-In2S3　can　be　recycled　and　kept　efficient　catalytic　performance　above　85%　even　after　reusing　for　four　times,　which　reflected　the　good　stability　and　relative　photocatalytic　activity　of　In2S3.　©,　2015,　Huanjing　Kexue/Environmental　Science.　All　right　reserved.