Earthquake　damage　of　water　supply　unit　is　predicted　on　the　basis　of　analyzing　the　pipeline　seismic　performance　function　and　the　limitation　state　equation.　Based　on　Monte　Carlo　method　and　neural　network,　the　running　state　and　the　destroy　state　of　each　pipeline　are　simulated.　And　the　reliability　of　the　water　supply　network　connectivity　is　analyzed　by　combining　with　graph　theory.　The　feasibility　of　this　method　is　verified　through　a　case　study.　©　2015,　Chongqing　Medical　University.　All　right　reserved.