Marine　algae　is　widely　distributed,　which　contains　high　nutritional　value.　Antimicrobial　substances　extracted　from　seaweed　has　become　the　focus　research.　There　is　a　great　prospect　for　application.　For　the　study　of　algae　Schizochytrium　meal　enzymatic　activity　of　the　crude　extracts,　the　optimal　enzymatic　hydrolysis　conditions　were　determined　for　the　recovery　of　the　highest　hydrolysates.　The　antibacterial　bioactivities　of　the　crude　extracts　were　tested　by　inhibition　zone　method　at　the　concentration　gradient　(120,100,80,60,40,20,0　mg/mL)with　E.　coli,　Staphylococcus　aureus　and　Salmonella　strains.　The　results　showed　that　algae　Schizochytrium　meal　crude　extracts　had　different　antibacterial　activities　against　E.　coli,　Staphylococcus　aureus,　Salmonella.　Extract　concentration　at　80mg/mL,　it　was　closely　to　100%　inhibition　of　action　against　E.　coli　and　Staphylococcus　aureus.　The　inhibitory　effect　on　Salmonella　was　relatively　weak　to　be　58%　of　inhibition　rate　when　cultured　for　12　h　at　concentration　of　120　mg/mL.　By　comparison　with　non-enzymatic　group,　the　inhibitory　effect　was　mainly　enzymatic　extracts.　©　2015,　Editorial　Office　of　Journal　of　CIFST.　All　right　reserved.