Most　of　the　present　anticancer　drugs　are　highly　cytotoxic　and　focus　mainly　on　killing　tumor　cells　rather　than　slowing　the　progress　of　cancer　metastasis.　Evidence　has　been　reported　that　bridges　the　mechanisms　of　inflammation　and　tumor　invasion.　Therefore,　we　evaluated　the　potency　in　cancer　metastasis　chemoprevention　of　compounds　and　a　coumarin　extracted　from　Murraya　exotica,　which　is　known　for　its　anti-inflammation　bioactivity.　By　carrying　out　experiments　in　vitro,　we　found　the　root　extracts　more　efficient　than　the　leaf　extracts　in　restraining　cell　migration　of　MDA-MB-231　cells,　while　leaf　extracts　presented　slightly　stronger　inhibition　of　tumor　cell　adhesion　at　low　concentrations.　In　addition,　compared　to　root　extracts,　a　novel　coumarin　identified　previously　from　root　extracts　showed　equal　inhibition　on　cancer　cell　adhesion　and　less　inhibition　on　cell　migration.　All　extracts　used　in　this　study　presented　low　cytotoxicity　in　vitro.　Through　comparison　of　the　contents　of　leaf　and　root　extracts　from　M　exotica,　several　compounds　are　considered　promising　against　cancer　metastasis.　This　study　evaluates　the　worth　of　further　development　of　M　exotica　to　find　its　effect　on　cancer　metastasis　chemoprevention.　©　2016,　©　The　Author(s)　2016.