According　to　the　location-routing　problem　that　the　total　relief　supplies　are　limited　and　insufficient　in　initial　stages　of　post-disaster,　the　priority　allocation　coefficient　of　each　point　is　determined　with　variable　set　theory　and　then　the　allocation　amount　of　relief　supplies　in　each　stricken　point　is　obtained.　Considering　the　construction　time　of　relief　facilities　and　relief　transportation　capacity　constraints,　the　location-　routing　model　is　proposed　with　the　goal　of　minimum　time　in　the　entire　rescue　process.　And　then　genetic　algorithm　is　used　to　solve　the　facility　location　and　relief　supplies　distribution　routing.　At　last,　the　effectiveness　and　feasibility　of　the　model　and　algorithm　are　verified　with　numerical　example.　Copyright　©　2016,　AIDIC　Servizi　S.r.l.