Recently　we　demonstrated　that　the　localized　surface　plasmon　resonance　(LSPR)　of　noble　metal　nanoparticles　would　significantly　enhance　the　electrochemiluminescence　(ECL)　emission　of　Ru(bpy)3　2+.　Based　on　this　finding,　we　developed　a　new　branch　of　surface　enhanced　spectroscopy　(SES),　namely,　surface　enhanced　electrochemiluminescence　(SEECL).　In　this　communication,　we　demonstrate　for　the　first　time　the　combination　of　SEECL　with　conventional　immunoassay　technique　to　develop　a　new　electroanalysis　method　called　surface　enhanced　electrochemiluminescence　immunoassay　(SEECL-IA).　The　proposed　method　is　demonstrated　for　the　detection　of　prostate　specific　antigen　(PSA),　and　the　results　show　that　our　method　can　detect　as　low　as　2.0×10−12　ng/mL　PSA　in　whole　blood　without　any　sample　pretreatment　process.　©　2016　WILEY-VCH　Verlag　GmbH　&　Co.　KGaA,　Weinheim