Generally,　well-constructed　gene　regulatory　models　can　serve　as　a　blueprint　for　researchers　to　understand　the　complex　regulatory　relationships　among　genes.　Since　the　traditional　models　and　methods　for　network　construction　are　with　low　accuracy,　and　do　not　reveal　detailed　mechanisms　among　in-cell　substances　related　to　gene　regulation,　we　present　here　a　new　dynamic　model　of　gene　regulation　with　reference　to　multisource　biological　information.　The　effectivity　of　our　proposed　method　is　verified　by　applying　it　to　a　collection　of　genes　in　the　yeast　genome.　The　experimental　result　shows　that　our　model　is　capable　to　discover　new　interaction　related　to　gene　regulation.　©　2016　IEEE.