In　this　work,　a　novel　and　high-efficiency　interface　has　been　developed　in　coupling　CE　with　inductively　coupled　plasma　MS　(ICPMS).　The　interface　completely　avoids　laminar　flow　in　CE　capillary　caused　by　the　suction　of　nebulizer,　and　can　be　easily　and　stably　operated　at　room　temperature　with　high　analyte　transport　efficiency　to　ICPMS.　The　new　interface　has　a　liquid　dead　volume　smaller　than　5　nL,　which　was　much　smaller　than　those　(65-2500　μL)　reported　previously　for　other　interfaces.　All　above　features　led　to　a　higher　sensitivity　and　a　better　electrophoretic　resolution　for　CE-ICPMS　coupled　with　this　new　interface.　With　the　help　of　this　new　interface,　we　have　successfully　separated　and　determined　five　species　of　arsenic,　As(III),　As(V),　monomethylarsonic　acid,　dimethylarsinic　acid　and　p-aminophenyl-arsonic　acid　using　CE-ICPMS　within　11　min　with　a　detection　limit　of　0.046-0.075　ng/mL　and　an　RSD　of　2-6%　(n=6).　©　2008　Wiley-VCH　Verlag　GmbH　&　Co.　KGaA,　Weinheim.