Four　amphipathic　cobalt(II),　nickel(II),　copper　(II),　and　zinc(II)　coordination　compounds　of　tetrakis-α-(2-methyl-8-quinolinoxy)　phthalocyanine　are　synthesized　using　＂DBU　catalytic　method＂.　The　titled　complexes　are　characterized　by　elemental　analysis,　mass　spectra,　UV-Vis,　and　IR　spectra.　In　addition,　the　rates　of　photo-generated　singlet　oxygen　and　the　rate　constants　of　photo-dynamic　oxidation　of　amino-acid　substrate　by　the　complexes　are　measured　under　the　optical　excitation　at　670　nm,　and　the　relations　between　their　structures　and　their　photosensitivities　are　discussed.　©　2008　Higher　Education　Press.