Electrochemical gene-function analysis for single cells with addressable microelectrode/microwell arrays - Details

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Abstract：

(Graph　Presented)　To　each　his　own:　An　addressable　electrochemical　device　consisting　of　orthogonally　arranged　rows　and　columns　of　electrodes　has　been　constructed　to　monitor　protein　expression　in　genetically　engineered　cells　at　the　single-cell　level.　The　response　based　on　redox　cycling　reflected　the　different　expression　levels　of　the　enzyme　from　individual　HeLa　cells　transfected　with　a　plasmid　vector　including　secreted　alkaline　phosphatase.　©　2009　Wiley-VCH　Verlag　GmbH　&　Co.　KGaA.

Keyword：

Biosensors; Electrochemistry; High-throughput screening; Microelectrodes; Single-cell analysis

Community：

[ 1 ] [Lin, Z.]Graduate School of Environmental Studies, Tohoku University, 6-6-11 Aoba, Aramaki, Sendai 980-8579, Japan
[ 2 ] [Lin, Z.]Ministry of Education Key Laboratory of Analysis and Detection Technology for Food Safety, Department of Chemistry, Fuzhou University, Fuzhou, Fujian 350002, China
[ 3 ] [Takahashi, Y.]Graduate School of Environmental Studies, Tohoku University, 6-6-11 Aoba, Aramaki, Sendai 980-8579, Japan
[ 4 ] [Murata, T.]Graduate School of Environmental Studies, Tohoku University, 6-6-11 Aoba, Aramaki, Sendai 980-8579, Japan
[ 5 ] [Takeda, M.]Graduate School of Environmental Studies, Tohoku University, 6-6-11 Aoba, Aramaki, Sendai 980-8579, Japan
[ 6 ] [Ino, K.]Graduate School of Environmental Studies, Tohoku University, 6-6-11 Aoba, Aramaki, Sendai 980-8579, Japan
[ 7 ] [Shiku, H.]Graduate School of Environmental Studies, Tohoku University, 6-6-11 Aoba, Aramaki, Sendai 980-8579, Japan
[ 8 ] [Matsue, T.]Graduate School of Environmental Studies, Tohoku University, 6-6-11 Aoba, Aramaki, Sendai 980-8579, Japan

Reprint 's Address：

[Lin, Z.]Graduate School of Environmental Studies, Tohoku University, 6-6-11 Aoba, Aramaki, Sendai 980-8579, Japan

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Source ：

Angewandte Chemie - International Edition

ISSN： 1433-7851

Year： 2009

Issue： 11

Volume： 48

Page： 2044-2046

1 1 . 8 2 9

JCR@2009

1 6 . 1 0 0

JCR@2023

JCR Journal Grade：1

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SCOPUS Cited Count： 56

ESI Highly Cited Papers on the List： 0 Unfold All

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Chinese Cited Count：

30 Days PV： 1

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