A　method　based　on　the　kinetics　stability　study　on　hydrolysis　of　chlorogenic　acid　by　capillary　zone　electrophoresis　with　electrochemical　detection　(CE-ED)　has　been　developed　in　this　paper.　Both　cyclic　and　hydrodynamic　voltammograms　of　chlorogenic　acid　and　its　hydrolysis　product　caffeic　acid　have　been　investigated.　The　conditions　for　separation　of　chlorogenic　acid　and　caffeic　acid,　such　as　the　buffer　pH　and　concentration,　the　separation　voltage,　and　the　injection　time　have　been　optimized.　Under　the　optimum　CE　running　conditions,　the　effects　of　reaction　temperature　and　pH　values　of　the　hydrolysis　solutions　on　the　hydrolysis　rate　constants　were　further　studied.　The　hydrolysis　rate　constants　of　chlorogenic　acid　were　obtained　from　the　concentration　change　of　hydrolysis　during　the　process　of　hydrolysis.　Based　on　the　fact,　a　simple　and　economical　method　for　the　determination　of　the　hydrolysis　rate　constant　and　activation　energy　of　hydrolysis　reaction　has　been　developed.　©　2008　Elsevier　B.V.　All　rights　reserved.