A　novel　non-enzymatic　electrochemiluminescence　(ECL)　sensor　based　on　palladium　nanoparticles　(PdNPs)-functional　carbon　nanotubes　(FCNTs)　was　discovered　for　glucose　detection.　PdNPs　were　homogeneously　modified　on　FCNTs　using　a　facile　spontaneous　redox　reaction　method.　Their　morphologies　were　characterized　by　transmission　electron　microscopy　(TEM).　Based　on　ECL　experimental　results,　the　PdNPs-FCNTs-Nafion　film　modified　electrode　displayed　high　electrocatalytic　activity　towards　the　oxidation　of　glucose.　The　free　radicals　generated　by　the　glucose　oxidation　reacted　with　the　luminol　anion　(LH-),　and　enhanced　the　ECL　signal.　Under　the　optimized　conditions,　the　linear　response　of　ECL　intensity　to　glucose　concentration　was　valid　in　the　range　from　0.5　to　40　μmol　L-1　(r2　=　0.9974)　with　a　detection　limit　(S/N　=　3)　of　0.09　μmol　L-1.　In　addition,　the　modified　electrode　presented　high　resistance　towards　the　poisoning　of　chloride　ion,　high　selectivity　and　long-term　stability.　In　order　to　verify　the　sensor　reliability,　it　was　applied　to　the　determination　of　glucose　in　glucose　injection　samples.　The　results　indicated　that　the　proposed　approach　provided　a　highly　sensitive,　more　facile　method　with　good　reproducibility　for　glucose　determination,　promising　the　development　of　a　non-enzymatic　ECL　glucose　sensor.　©　2009　Elsevier　B.V.　All　rights　reserved.