Inflammatory Micro-environment Contributes to Stemness Properties and Metastatic Potential of HCC via the NF-κB/miR-497/SALL4 Axis - Details

author：

Indexed by：

Scopus

Abstract：

Increasing　evidence　has　demonstrated　the　essential　role　of　inflammatory　micro-environment　in　tumorigenesis　and　tumor　progression.　Some　cancer　cells　in　tumor　maintain　typical　stemness　properties　and,　with　the　capacity　of　self-renewal,　are　thought　to　be　crucial　for　the　initiation　and　maintenance　of　tumors　as　well　as　their　metastasis.　Although　both　inflammatory　micro-environment　and　stemness　properties　played　crucial　roles　in　tumor　initiation　and　development,　currently　it　is　still　unclear　whether　and　how　the　inflammatory　micro-environment　promotes　cancer　stemness　properties.　Here,　we　show　the　first　evidence　that　the　inflammatory　micro-environment　promotes　the　stemness　properties　and　metastatic　potential　of　hepatocellular　carcinoma　(HCC)　via　the　NF-κB/miR-497/SALL4　axis.　We　discover　that　miR-497　directly　targets　SALL4,　negatively　regulates　its　expression,　and　further　inhibits　the　self-renewal　and　metastasis　of　HCC;　more　importantly,　inflammatory　factor　TNF-α　inhibits　the　expression　of　miR-497　via　NF-kB-mediated　negative　transcriptional　regulation　and　simultaneously　upregulates　the　expression　of　SALL4　and　promotes　the　self-renewal　and　metastasis　phenotypes　of　HCC　cells.　Moreover,　lower　expression　of　miR-497　is　significantly　associated　with　poor　prognosis　in　HCC　patients.　Taken　together,　our　findings　not　only　revealed　a　novel　signaling　pathway　(NF-κB/miR-497/SALL4　axis)　to　connect　inflammation　with　stemness　properties,　and　clarified　the　molecular　mechanisms　underlying　the　inflammation-mediated　self-renewal　and　metastasis　phenotypes,　but　also　provided　novel　molecular　targets　for　developing　new　anticancer　strategies.　©　2019　The　Authors

Keyword：

hepatocellular carcinoma; inflammation; metastasis; miR-497; NF-κB; SALL4; stemness

Community：

[ 1 ] [Zhao, B.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 2 ] [Zhao, B.]Mengchao Med-X Center, Fuzhou University, Fuzhou, 350116, China
[ 3 ] [Zhao, B.]The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, 350025, China
[ 4 ] [Wang, Y.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 5 ] [Wang, Y.]Mengchao Med-X Center, Fuzhou University, Fuzhou, 350116, China
[ 6 ] [Wang, Y.]The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, 350025, China
[ 7 ] [Tan, X.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 8 ] [Tan, X.]The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, 350025, China
[ 9 ] [Ke, K.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 10 ] [Ke, K.]The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, 350025, China
[ 11 ] [Zheng, X.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 12 ] [Zheng, X.]The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, 350025, China
[ 13 ] [Wang, F.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 14 ] [Wang, F.]The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, 350025, China
[ 15 ] [Lan, S.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 16 ] [Lan, S.]The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, 350025, China
[ 17 ] [Liao, N.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 18 ] [Liao, N.]Mengchao Med-X Center, Fuzhou University, Fuzhou, 350116, China
[ 19 ] [Liao, N.]The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, 350025, China
[ 20 ] [Cai, Z.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 21 ] [Cai, Z.]Mengchao Med-X Center, Fuzhou University, Fuzhou, 350116, China
[ 22 ] [Cai, Z.]The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, 350025, China
[ 23 ] [Shi, Y.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 24 ] [Shi, Y.]The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, 350025, China
[ 25 ] [Zheng, Y.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 26 ] [Zheng, Y.]Mengchao Med-X Center, Fuzhou University, Fuzhou, 350116, China
[ 27 ] [Zheng, Y.]The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, 350025, China
[ 28 ] [Lai, Y.]Department of Hepatobiliary and Pancreatic Surgery, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 29 ] [Wang, L.]Department of Diagnostic Radiology, Fujian Medical University Union Hospital, Fuzhou, 350001, China
[ 30 ] [Li, Q.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 31 ] [Li, Q.]Mengchao Med-X Center, Fuzhou University, Fuzhou, 350116, China
[ 32 ] [Li, Q.]The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, 350025, China
[ 33 ] [Liu, J.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 34 ] [Liu, J.]Mengchao Med-X Center, Fuzhou University, Fuzhou, 350116, China
[ 35 ] [Liu, J.]The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, 350025, China
[ 36 ] [Huang, A.]Department of Pathology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, 350108, China
[ 37 ] [Huang, A.]The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, 350025, China
[ 38 ] [Liu, X.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 39 ] [Liu, X.]Mengchao Med-X Center, Fuzhou University, Fuzhou, 350116, China
[ 40 ] [Liu, X.]The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, 350025, China

Reprint 's Address：

[Huang, A.]Department of Pathology, School of Basic Medical Sciences, Fujian Medical University, 1 Xueyuan Road, China

Email：

aimin@fjmu.edu.cn

Show more details

Related Keywords：

Source ：

Molecular Therapy - Oncolytics

ISSN： 2372-7705

Year： 2019

Volume： 15

Page： 79-90

4 . 1 1 5

JCR@2019

5 . 3 0 0

JCR@2023

ESI HC Threshold：291

JCR Journal Grade：2

CAS Journal Grade：3

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count： 31

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 0

Affiliated Colleges：

Get Fulltext

DOI Library Discovery Baidu Scholar Search SCOPUS

Type
Departments

All Years Choose Year From to