In　this　paper,　a　new　Orthogonal　QUasi-Affine　TRansformation　Evolution　(O-QUATRE)　algorithm　was　proposed　for　global　optimization.　The　O-QUATRE　algorithm　is　actually　implemented　as　a　combination　of　both　the　QUATRE　algorithm　and　the　orthogonal　array,　both　of　which　together　secured　an　overall　better　performance　on　complex　optimization　problems.　The　proposed　algorithm　is　verified　under　CEC2013　test　suite　for　real-parameter　optimization.　The　experimental　results　indicated　that　the　proposed　O-QUATRE　algorithm　obtained　better　mean　and　standard　deviation　of　fitness　error　than　QUATRE　algorithm,　which　means　that　the　O-QUATRE　algorithm　was　of　more　robustness　and　better　stability.　©　Springer　Nature　Singapore　Pte　Ltd.　2020.