NIR/ROS-Responsive Black Phosphorus QD Vesicles as Immunoadjuvant Carrier for Specific Cancer Photodynamic Immunotherapy - Details

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Abstract：

2D　black　phosphorus　(BP)　nanosheets　and　BP　quantum　dots　(BPQD),　as　two　main　material　styles　of　BP,　are　widely　used　in　the　biomedical　filed.　However,　few　stimuli-responsive　BP　nanocarriers　are　reported　to　meet　the　need　of　nanomedicine.　Herein,　near-infrared　region/reactive　oxygen　species　(NIR/ROS)　sensitive　BPQD　vesicles　(BPNVs)　are　prepared　by　self-assembly　of　amphiphilic　BPQDs　grafted　with　polyethylene　glycol　and　ROS　sensitive　poly(propylene　sulfide)　(PPS).　BPNVs　exhibit　enhanced　photo-absorption　in　the　NIR　region,　and　have　high　loading　efficiency　of　immunoadjuvant　CpG　oligodeoxynucleotides　(CpG　ODNs)　in　the　cavity　of　the　BPNVs.　Upon　NIR　laser　irradiation,　high　levels　of　ROS　are　generated　from　BPNVs　to　trigger　the　change　of　hydrophobic　PPS　to　hydrophilic　polymers,　leading　to　disassembly　of　the　vesicles　to　BPQDs.　In　this　manner,　the　BPNVs　show　synergistic　photodynamic　therapy　combined　with　immunotherapy,　due　to　simultaneous　release　of　small　BPQDs　with　deep　tumor　penetration　and　CpG　with　enhanced　immunotherapy.　The　BPNVs-CpG　achieves　potent　photodynamic　immunotherapy　in　vivo,　in　addition　to　block　distant　tumor　growth　and　metastasis.　©　2019　WILEY-VCH　Verlag　GmbH　&　Co.　KGaA,　Weinheim

Keyword：

black phosphorus quantum dots; immunotherapy; photoacoustic imaging; photodynamic therapy; self-assembly

Community：

[ 1 ] [Li, Z.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 2 ] [Hu, Y.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 3 ] [Fu, Q.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 4 ] [Liu, Y.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 5 ] [Wang, J.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 6 ] [Song, J.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 7 ] [Yang, H.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, China

Reprint 's Address：

[Song, J.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou UniversityChina

Email：

jibinsong@fzu.edu.cn

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Source ：

Advanced Functional Materials

ISSN： 1616-301X

Year： 2020

Issue： 3

Volume： 30

1 8 . 8 0 8

JCR@2020

1 8 . 5 0 0

JCR@2023

ESI HC Threshold：196

JCR Journal Grade：1

CAS Journal Grade：1

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count： 105

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 3

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