Catalytic　dehydrogenation　of　propane　over　a　Pt-based　catalyst　to　propylene　has　received　considerable　interests　in　recent　years　because　this　route　is　able　to　provide　an　economical　and　efficient　way　to　fill　the　gap　between　supply　and　demand　in　propylene　market.　The　low　dispersion　of　a　Pt　particle　at　the　support　surface　and　sintering　of　Pt　nanoparticles　under　the　harsh　reaction　condition　are　the　main　challenges　in　the　practical　application　of　this　catalyst.　Herein,　highly　efficient　Pt/Sn-Beta　catalysts　are　developed　for　propane　dehydrogenation,　which　exhibits　high　activity,　selectivity,　and　stability　in　this　reaction.　Full　characterizations　with　XRD,　STEM,　XPS,　CO-IR,　H2-TPR,　and　Py-IR　techniques　on　these　catalysts　reveal　that　the　Pt　clusters　are　localized　at　the　Sn　single-site　in　the　zeolitic　framework,　which　allows　the　generated　Pt　clusters　to　be　homogeneously　dispersed　at　the　surface　zeolite.　The　high　performance　of　Pt/Sn-Beta　catalysts　under　a　high　reaction　temperature　is　mainly　due　to　a　strong　interaction　between　the　Pt　cluster　and　Sn-zeolite.　An　initial　propane　conversion　of　50%,　high　propylene　selectivity　of　above　99%,　low　deactivation　rate　of　0.006　h-1,　high　TOF　of　114　s-1,　and　good　regenerability　have　been　achieved　in　the　Pt-Sn2.00/Sn-Beta　catalyst　for　propane　dehydrogenation　at　570　°C.　Copyright　©　2019　American　Chemical　Society.