Nickel-Catalyzed C-O Cross-Coupling Reaction at Low Catalytic Loading with Weak Base Participation - Details

author：

Wu, F. (Wu, F..) ^[1] | Zhu, K. (Zhu, K..) ^[2] | Wu, G. (Wu, G..) ^[3] | Gao, Y. (Gao, Y..) ^[4] | Chen, H. (Chen, H..) ^[5]

Indexed by：

Scopus

Abstract：

Herein,　we　report　a　nickel-catalyzed　crossing-coupling　reaction　for　the　synthesis　of　diaryl　ethers.　The　desired　products　are　achieved　by　coupling　heterocyclic　alcohols　with　aryl　bromides　bearing　strong　electron　withdrawing　nitro　group　under　the　catalyst　system　of　NiCl2(PPh3)2　and　weak　base　KHCO3.　This　mild　reaction　exhibits　a　broad　functional　group　tolerance.　Compound　4　as　an　important　intermediate　is　suitable　for　further　structural　modification　of　MALT1　inhibitor　MI-2.　©　2019　WILEY-VCH　Verlag　GmbH　&　Co.　KGaA,　Weinheim

Keyword：

Cross-coupling; Homogeneous catalysis; Oxidative addition; Synthetic methods; Weak bases

Community：

[ 1 ] [Wu, F.]Key Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China
[ 2 ] [Zhu, K.]Key Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China
[ 3 ] [Wu, G.]Key Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China
[ 4 ] [Gao, Y.]Key Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China
[ 5 ] [Chen, H.]Key Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China

Reprint 's Address：

[Chen, H.]Key Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), College of Chemistry, Fuzhou UniversityChina

Email：

chenhaij@gmail.com

Show more details

Related Keywords：

Source ：

European Journal of Organic Chemistry

ISSN： 1434-193X

Year： 2020

Issue： 4

Volume： 2020

Page： 519-522

2 . 5 0 0

JCR@2023

ESI HC Threshold：160

JCR Journal Grade：2

CAS Journal Grade：3

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count： 7

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 1

Affiliated Colleges：

Get Fulltext

DOI Library Discovery Baidu Scholar Search SCOPUS

Type
Departments

All Years Choose Year From to