Effects of hydroxyl radicals produced by a zinc phthalocyanine photosensitizer on tumor DNA - Details

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Abstract：

Photodynamic　therapy　(PDT)　is　a　new　therapeutic　approach　for　cancer　treatment.　Its　mechanism　relies　on　three　elements:　photosensitizer,　light　and　oxygen.　Under　aerobic　conditions,　a　suitable　wavelength　of　light　activates　the　photosensitizer　that　results　in　the　formation　of　reactive　oxygen　species　(ROS).　We　herein　report　that　PDT　with　a　zinc　phthalocyanine　(ZnPc)　photosensitizer　coupled　with　2,4,6-tris　(N,　N-dimethylaminomethyl)　phenoxy　(TAP),　termed　as　ZnPc(TAP)4,　has　the　ability　to　photodegrade　DNA　in　tumor　cells　via　hydroxyl　radicals　produced　under　the　red　light　irradiation,　resulting　in　effective　elimination　of　tumor　cells.　Furthermore,　the　high-efficient　anti-tumor　effect　of　ZnPc(TAP)4　was　verified　in　a　human　breast　adenocarcinoma　cell　line　MCF-7　tumor-bearing　animal　model.　To　the　best　of　our　knowledge,　this　is　the　first　time　that　destructive　effects　of　hydroxyl　radicals　produced　by　PDT　on　DNA　of　tumor　cells　has　been　documented,　which　may　open　up　new　avenues　of　antitumor　therapy　on　eliminating　the　DNA　of　tumor　cells.　©　2019

Keyword：

Cell DNA; Photocleavage; Photodynamic therapy; Photosensitizer; Phthalocyanine

Community：

[ 1 ] [Yan, S.]State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China
[ 2 ] [Yan, S.]Medical Plant Exploitation and Utilization Engineering Research Center, Sanming University, Sanming, Fujian 365004, China
[ 3 ] [Guo, H.]State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China
[ 4 ] [Guo, H.]University of Chinese Academy of Sciences, Beijing, 100049, China
[ 5 ] [Su, J.]Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, China
[ 6 ] [Chen, J.]State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China
[ 7 ] [Chen, J.]University of Chinese Academy of Sciences, Beijing, 100049, China
[ 8 ] [Song, X.]State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China
[ 9 ] [Huang, M.]College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China
[ 10 ] [Zhang, J.]Medical Plant Exploitation and Utilization Engineering Research Center, Sanming University, Sanming, Fujian 365004, China
[ 11 ] [Chen, Z.]State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China
[ 12 ] [Chen, Z.]University of Chinese Academy of Sciences, Beijing, 100049, China

Reprint 's Address：

[Chen, Z.]State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of SciencesChina

Email：

zchen@fjirsm.ac.cn

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Source ：

Dyes and Pigments

ISSN： 0143-7208

Year： 2020

Volume： 173

4 . 8 8 9

JCR@2020

4 . 1 0 0

JCR@2023

ESI HC Threshold：160

JCR Journal Grade：1

CAS Journal Grade：1

Cited Count：

WoS CC Cited Count： 0

SCOPUS Cited Count： 12

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 2

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