Endoplasmic Reticulum Targeting to Amplify Immunogenic Cell Death for Cancer Immunotherapy - Details

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Abstract：

Immunogenic　cell　death　(ICD)　elicited　by　photodynamic　therapy　(PDT)　is　mediated　through　generation　of　reactive　oxygen　species　(ROS)　that　induce　endoplasmic　reticulum　(ER)　stress.　However,　the　half-life　of　ROS　is　very　short　and　the　intracellular　diffusion　depth　is　limited,　which　impairs　ER　localization　and　thus　limits　ER　stress　induction.　To　solve　the　problem,　we　synthesized　reduction-sensitive　Ds-sP　NPs　(PEG-s-s-1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene　glycol)-2000]　nanoparticles)　loaded　with　an　efficient　ER-targeting　photosensitizer　TCPP-TER　(4,4′,4″,4′″-(porphyrin-5,10,15,20-tetrayl)tetrakis(N-(2-((4-methylphenyl)sulfonamido)ethyl)benzamide).　The　resulting　Ds-sP/TCPP-TER　NPs　could　selectively　accumulate　in　the　ER　and　locally　generate　ROS　under　near-infrared　(NIR)　laser　irradiation,　which　induced　ER　stress,　amplified　ICD,　and　activated　immune　cells,　leading　to　augmented　immunotherapy　effect.　This　study　presents　a　novel　ICD　amplifying,　ER-targeting　PDT　strategy　that　can　effectively　eradicate　primary　tumors　under　NIR　exposure,　as　well　as　distant　tumors　through　an　abscopal　effect.　Copyright　©　2020　American　Chemical　Society.

Keyword：

abscopal effect; Endoplasmic reticulum (ER) stress; Immunogenic cell death (ICD); Photodynamic therapy

Community：

[ 1 ] [Deng, H.]Moe Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 2 ] [Deng, H.]Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892, United States
[ 3 ] [Zhou, Z.]Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892, United States
[ 4 ] [Yang, W.]Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892, United States
[ 5 ] [Lin, L.-S.]Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892, United States
[ 6 ] [Wang, S.]Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892, United States
[ 7 ] [Niu, G.]Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892, United States
[ 8 ] [Song, J.]Moe Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 9 ] [Chen, X.]Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892, United States

Reprint 's Address：

[Song, J.]Moe Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou UniversityChina

Email：

jibinsong@fzu.edu.cn

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Source ：

Nano Letters

ISSN： 1530-6984

Year： 2020

Issue： 3

Volume： 20

Page： 1928-1933

1 1 . 1 8 9

JCR@2020

9 . 6 0 0

JCR@2023

ESI HC Threshold：196

JCR Journal Grade：1

CAS Journal Grade：1

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count： 287

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 0

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