Draw　solute　is　a　key　element　of　forward　osmosis　(FO)　technology.　Here　we　design　a　cage-like　supramolecular　material　of　N-(hexamethylenetetramine)　propane-1-sulfonate　(HMTA+　−　SO3−)　for　the　simultaneous　wastewater　remediation　and　protein　enrichment　via　FO　processes.　HMTA+　−　SO3−　reclaims　water　efficiently　with　a　transfer　rate　of　36.0　LMH　at　1.0　M　without　reverse　solute　diffusion,　outperforming　the　conventional　NaCl　draw　solute　that　produces　a　smaller　water　flux　coupled　with　severe　solute　leakage.　The　good　performance　originates　from　the　innate　nature　of　HMTA+　−　SO3−　that　can　create　a　sufficiently　high　osmotic　pressure　to　drive　the　FO　process　and　form　a　supramolecular　network　with　H2O　via　hydrogen-bonding　to　prevent　solute　leakage.　Protein　enriched　by　HMTA+　−　SO3−　remains　intact　in　structure　but　those　concentrated　by　typical　NH4HCO3　or　NaCl　draw　solutes　are　either　contaminated　or　denatured　resulting　from　the　severe　reverse　solute　diffusion　in　the　FO　process.　HMTA+　−　SO3−　can　be　readily　collected　quantitatively　via　precipitation　purification　and　reused　with　reproducible　results.　The　HMTA+　−　SO3−　facilitated　FO　process　for　protein-containing　wastewater　treatment　reported　here　may　ultimately　find　use　in　processing　other　high-value-added　compounds.　©　2020　Elsevier　B.V.