Near-infrared-excited upconversion photodynamic therapy of extensively drug-resistant: Acinetobacter baumannii based on lanthanide nanoparticles - Details

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Abstract：

Extensively　drug-resistant　Acinetobacter　baumannii　(XDR-AB)　has　raised　considerable　concerns　due　to　its　mortal　damage　to　humans　and　its　high　transmission　rate　of　infections　in　hospitals.　However,　current　antibiotics　not　only　show　poor　anti-infection　effects　in　vivo　but　also　frequently　cause　high　nephrotoxicity　and　neurotoxicity.　Herein,　we　report　a　near-infrared　(NIR)　light-initiated　antimicrobial　photodynamic　therapy　(aPDT)　to　effectively　treat　in　vivo　XDR-AB　infections　based　on　photosensitizer　(PS)　loaded　upconversion　nanoparticles　(UCNPs,　LiYF4:Yb/Er).　Such　nanoagents　feature　robust　NIR　triggered　UC　luminescence　and　high-efficiency　energy　transfer　from　UCNPs　to　the　loaded　PS,　thereby　allowing　NIR-triggered　generation　of　reactive　oxygen　species　(ROS)　for　destroying　the　bacterial　cell　membrane.　This　strategy　permits　a　high　antibacterial　activity　against　XDR-AB,　resulting　in　a　decline　of　4.72　log10　in　viability　at　a　dose　of　50　µg　mL-1　UCNPs-PVP-RB　with　980　nm　laser　irradiation　(1　W　cm-2).　More　significantly,　we　can　achieve　excellent　therapeutic　efficacy　against　deep-tissue　(about　5　mm)　XDR-AB　infections　without　causing　any　side　effects　in　the　murine　model.　In　brief,　such　NIR-activated　aPDT　may　open　up　new　avenues　for　treating　various　deep-tissue　intractable　infections.　©　2020　The　Royal　Society　of　Chemistry.

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[ 1 ] [Liu, W.]State Key Laboratory of Structural Chemistry, CAS Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Key Laboratory of Nanomaterials, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fujian College, University of Chinese Academy of Sciences, Fuzhou Fujian, 350002, China
[ 2 ] [Liu, W.]University of Chinese Academy of Sciences, Beijing, 100049, China
[ 3 ] [Zhang, Y.]State Key Laboratory of Structural Chemistry, CAS Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Key Laboratory of Nanomaterials, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fujian College, University of Chinese Academy of Sciences, Fuzhou Fujian, 350002, China
[ 4 ] [Zhang, Y.]University of Chinese Academy of Sciences, Beijing, 100049, China
[ 5 ] [You, W.]State Key Laboratory of Structural Chemistry, CAS Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Key Laboratory of Nanomaterials, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fujian College, University of Chinese Academy of Sciences, Fuzhou Fujian, 350002, China
[ 6 ] [Su, J.]Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen Fujian, 361021, China
[ 7 ] [Yu, S.]State Key Laboratory of Structural Chemistry, CAS Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Key Laboratory of Nanomaterials, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fujian College, University of Chinese Academy of Sciences, Fuzhou Fujian, 350002, China
[ 8 ] [Yu, S.]University of Chinese Academy of Sciences, Beijing, 100049, China
[ 9 ] [Dai, T.]State Key Laboratory of Structural Chemistry, CAS Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Key Laboratory of Nanomaterials, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fujian College, University of Chinese Academy of Sciences, Fuzhou Fujian, 350002, China
[ 10 ] [Dai, T.]University of Chinese Academy of Sciences, Beijing, 100049, China
[ 11 ] [Huang, Y.]Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou Fujian, 350122, China
[ 12 ] [Chen, X.]State Key Laboratory of Structural Chemistry, CAS Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Key Laboratory of Nanomaterials, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fujian College, University of Chinese Academy of Sciences, Fuzhou Fujian, 350002, China
[ 13 ] [Chen, X.]University of Chinese Academy of Sciences, Beijing, 100049, China
[ 14 ] [Song, X.]Institute of Environmental Analysis and Monitoring, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou Fujian, 350116, China
[ 15 ] [Chen, Z.]State Key Laboratory of Structural Chemistry, CAS Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Key Laboratory of Nanomaterials, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fujian College, University of Chinese Academy of Sciences, Fuzhou Fujian, 350002, China
[ 16 ] [Chen, Z.]University of Chinese Academy of Sciences, Beijing, 100049, China

Reprint 's Address：

[Chen, Z.]State Key Laboratory of Structural Chemistry, CAS Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Key Laboratory of Nanomaterials, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fujian College, University of Chinese Academy of Sciences, Institute of Environmental Analysis and Monitoring, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou UniversityChina

Email：

zchen@fjirsm.ac.cn

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Nanoscale

ISSN： 2040-3364

Year： 2020

Issue： 26

Volume： 12

Page： 13948-13958

7 . 7 9

JCR@2020

5 . 8 0 0

JCR@2023

ESI HC Threshold：115

JCR Journal Grade：1

CAS Journal Grade：2

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count： 43

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 4

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