Cancer Cell-Targeted Photosensitizer and Therapeutic Protein Co-Delivery Nanoplatform Based on a Metal-Organic Framework for Enhanced Synergistic Photodynamic and Protein Therapy - Details

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Abstract：

Efficient　and　cancer　cell-Targeted　delivery　of　photosensitizer　(PS)　and　therapeutic　protein　has　great　potentiality　for　improving　the　anticancer　effects.　Herein,　zeolitic　imidazolate　framework-8　(ZIF-8)　nanoparticles,　one　of　the　most　attractive　metal-organic　framework　materials,　were　used　for　coencapsulating　the　chlorin　e6　(Ce6,　a　potent　PS)　and　cytochrome　c　(Cyt　c,　a　protein　apoptosis　inducer);　then　the　nanoparticle　was　subsequently　decorated　with　the　hyaluronic　acid　(HA)　shell　to　form　cancer　cell-Active　targeted　nanoplatform　(Ce6/Cyt　c@ZIF-8/HA).　The　in　vitro　and　in　vivo　experiments　show　the　cancer　cell　targeting　capability　and　pH-responsive　decomposition　and　the　release　behavior　of　Ce6/Cyt　c@ZIF-8/HA.　Upon　light　irradiation,　the　released　Ce6　produced　cytotoxic　reactive　oxygen　species　for　photodynamic　therapy.　Meanwhile,　the　released　Cyt　c-induced　programmed　cell　death　for　protein　therapy.　Furthermore,　the　Cyt　c　worked　normally　under　hypoxia　conditions　and　could　decompose　H2O2　to　O2　(with　peroxidase-/catalase-like　activity),　resulting　in　synergistically　improved　therapeutic　efficiency.　These　small　molecules　and　protein　codelivery　nanoplatforms　would　promote　the　development　of　complementary　and　synergetic　modes　for　biomedical　applications.　Copyright　©　2020　American　Chemical　Society.

Keyword：

cytochrome c; hypoxia; photodynamic therapy; protein therapy; zeolitic imidazolate framework-8

Community：

[ 1 ] [Ding, L.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350116, China
[ 2 ] [Ding, L.]United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 3 ] [Lin, X.]Department of Critical Care Medicine, Hospital of Fujian Medical University, Fuzhou, 350005, China
[ 4 ] [Lin, Z.]United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 5 ] [Wu, Y.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350116, China
[ 6 ] [Wu, Y.]United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 7 ] [Wu, Y.]Mengchao Med-X Center, Fuzhou University, Fuzhou, 350116, China
[ 8 ] [Liu, X.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350116, China
[ 9 ] [Liu, X.]United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 10 ] [Liu, X.]Mengchao Med-X Center, Fuzhou University, Fuzhou, 350116, China
[ 11 ] [Liu, J.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350116, China
[ 12 ] [Liu, J.]United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 13 ] [Liu, J.]Mengchao Med-X Center, Fuzhou University, Fuzhou, 350116, China
[ 14 ] [Liu, J.]Liver Disease Center, Hospital of Fujian Medical University, Fuzhou, 350005, China
[ 15 ] [Wu, M.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350116, China
[ 16 ] [Wu, M.]United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 17 ] [Wu, M.]Mengchao Med-X Center, Fuzhou University, Fuzhou, 350116, China
[ 18 ] [Zhang, X.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350116, China
[ 19 ] [Zhang, X.]United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 20 ] [Zhang, X.]Mengchao Med-X Center, Fuzhou University, Fuzhou, 350116, China
[ 21 ] [Zeng, Y.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350116, China
[ 22 ] [Zeng, Y.]United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 23 ] [Zeng, Y.]Mengchao Med-X Center, Fuzhou University, Fuzhou, 350116, China
[ 24 ] [Zeng, Y.]Liver Disease Center, Hospital of Fujian Medical University, Fuzhou, 350005, China

Reprint 's Address：

[Zhang, X.]College of Biological Science and Engineering, Fuzhou University, College of Biological Science and Engineering, Fuzhou UniversityChina

Email：

xiaolongdo@gmail.com

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ACS Applied Materials and Interfaces

ISSN： 1944-8244

Year： 2020

Issue： 33

Volume： 12

Page： 36906-36916

9 . 2 2 9

JCR@2020

8 . 5 0 0

JCR@2023

ESI HC Threshold：196

JCR Journal Grade：1

CAS Journal Grade：2

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SCOPUS Cited Count：

ESI Highly Cited Papers on the List： 0 Unfold All

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30 Days PV： 0

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