Acute　full-thickness　wounds　require　a　more　extended　healing　period,　thus　increasing　the　risk　of　infection.　Severe　infection　frequently　resulted　in　wound　ulceration,　necrosis,　and　even　life-threatening　complications.　Here,　a　hybrid　hydrogel　comprising　aminated　collagen　(AC),　oxidized　sodium　alginate　(OSA),　and　antimicrobial　peptides　(polymyxin　B　sulfate　and　bacitracin)　was　developed　to　enhance　full-thickness　wound　healing.　The　AC　with　low　immunogenicity　and　high　biocompatibility　was　made　from　marine　fish　scales,　which　are　eco-friendly,　low-cost,　and　sustainable.　The　cross-linked　hydrogel　was　formed　by　a　Schiff　base　reaction　without　any　catalysts　and　additional　procedures.　As　expected,　the　presented　hybrid　hydrogel　can　effectively　against　E.　coli　and　S.　aureus,　as　well　as　promote　cell　growth　and　angiogenesis　in　vitro.　In　addition,　the　hydrogel　can　promote　full-thickness　wound　healing　in　a　rat　model　through　accelerating　reepithelialization,　collagen　deposition,　and　angiogenesis.　Our　work　demonstrated　that　the　hybrid　hydrogel　has　promising　applications　in　the　field　of　wound　healing,　which　would　prompt　the　utilization　of　marine　fish　resources　during　food　processing.　©　2020　Elsevier　B.V.