To　improve　the　performance　of　catalytic　cracking　(FCC)　gasoline　selective　hydrodesulfurization　catalyst,　the　alumina　support　containing　macroporous　structure　was　prepared　by　carboxymethyl　cellulose　pore-enlarging　method　and　then　was　used　to　prepare　CoMoS　catalyst.　N2　adsorption-desorption,　mercury　intrusion　method,　and　NH3　temperature　programmed　desorption　(NH3-TPD)　were　used　to　characterize　the　pore　size　distributions　and　acidity　of　the　support　before　and　after　pore-enlarging　treatment.　The　results　indicated　that　the　intrinsic　pore　size　distributions　and　acidity　were　almost　the　same,　but　new　macropore　at　about　150　nm　appeared.　The　hydrodesulfurization　reaction　performance　of　the　prepared　catalyst　was　evaluated　using　industrial　FCC　gasoline.　Compared　with　the　untreated　alumina　support,　the　desulfurization　selectivity　of　the　catalyst　supported　on　the　alumina　containing　macroporous　structure　was　greatly　improved.　The　industrial　application　results　on　a　1.2　million　tons/year　gasoline　hydrogenation　unit　in　China　indicated　that　the　octane　number　loss　was　0.6　under　the　condition　of　90%　desulfurization　rate.　©　2019,　Editorial　Board　of　Journal　of　Chemical　Reaction　Engineering　and　Technology.　All　right　reserved.