The　seismic　response　of　mid-story　isolation　eccentric　structure　with　tower-podium　is　investigated　to　guide　the　seismic　design　of　such　vertical　irregular　structures.A　representative　model　of　mid-story　isolation　eccentric　structure　with　a　large　podium　was　fabricated.　The　large　podium　has　two　stories　and　the　tower　has　six　stories.　The　isolation　layer　is　located　at　the　bottom　of　the　tower.Numerical　analysis　and　shaking　table　test　were　conducted　on　a　mid-story　isolation　model　and　an　anti-seismic　model　without　an　isolation　system　to　compare　their　seismic　response.　These　models　were　subjected　to　bidirectional　seismic　waves,　and　a　total　of　16　test　scenarios　were　obtained.　The　results　show　that　for　the　mid-story　isolation　model,　the　story　acceleration　and　story　drift　of　each　story　of　the　tower　decreases　sharply,　indicating　an　excellent　damping　effect　on　the　tower.　The　story　acceleration　response　and　the　story　drift　of　the　podium　increase　slightly,　which　indicates　that　there　is　almost　no　damping　effect　on　the　podium.　The　podium　enters　into　the　elastic-plastic　stage　under　the　peak　acceleration　of　0.4g,　and　a　medium　damage　level　was　reached　under　the　peak　acceleration　of　0.6g.It　is　thus　suggested　that　the　stressed　components　of　the　podium　should　be　strengthened,　and　the　limit　of　elastic-plastic　displacement　angle　of　the　podium　should　be　increased　in　engineering　application.　©　2019,　The　Editorial　Board　of　Journal　of　Basic　Science　and　Engineering.　All　right　reserved.