The　adverse　impacts　on　base-isolated　high-rise　structures　using　friction　pendulums　bearings　will　be　exerted　when　subjected　to　near-fault　ground　motions　featured　by　horizontal　pulse　motions　of　acceleration　with　long　period,　short　duration　and　high　energy,　and　the　soil-structure　interaction　(SSI)　which　will　result　in　a　dynamic　coupling　effect,　may　further　amplify　the　seismic　response　of　an　isolated　structure.　To　this　end,　by　nonlinear　seismic　response　analysis　of　a　frame-core　tube　base-isolated　high-rise　structure　using　friction　pendulums,　the　impacts　of　near-fault　pulse　ground　motions　on　the　inter-story　drift　ratios,　inter-story　shear　forces　as　well　as　deformation　of　isolation　layer　are　revealed,　and　the　damage　mechanism　of　isolation　system　is　examined.　Further,　based　on　sway-rocking　model,　the　effects　of　different　site　types　and　different　ground　motion　types　on　the　dynamic　response　of　isolation　system　are　analyzed.　The　results　show　that　the　damping　effects　of　the　base-isolated　high-rise　structures　using　friction　pendulums　when　subjected　to　near-fault　pulse　ground　motions　become　worse　than　those　when　subjected　to　ordinary　ground　motions,　the　inter-story　drift　ratios,　inter-story　shear　forces　as　well　as　deformation　of　isolation　layer　are　1.5　times　greater　than　that　of　ordinary　ground　motions.　On　Ⅲ　and　Ⅳ　sites,　the　nonlinear　seismic　response　of　isolated　structures　is　enlarged　by　considering　the　SSI　effect.　The　inter-story　drift　ratios　increase　obviously　with　the　soil　softening.　©　2019,　Editorial　Board　of　World　Earthquake　Engineering.　All　right　reserved.