Objective:　To　explore　the　anti-obesity　effect　of　Monascus-fermented　Radix　Puerariae　extracts(MRPE)　on　high-fat　induced　obese　C57BL/6J　mice.　Method.　Thirty-two　C57BL/6J　mice　were　fed　with　high-fat　diet　to　induce　obesity.　Then,　the　32　obese　mice　were　irrigated　with　distilled　water　(HF　group,　n　=　8),　Monacolin　K　(MK　group,　n　=　8),　normal　dose　of　MRPE　(MRPE-C　group,　n　=　8),　and　high　dose　of　MRPE(MRPE-H　group,　n　=　8),　respectively.　After　4　weeks,　the　body　weights,　body　lengths,　abdominal　fat,　body-fat　ratio　and　Lee＇s　index　were　recorded.　Moreover,　serum　total　cholesterol,　triglyceride,　HDL,　LDL　and　serum　lipopolysaccharide　(LBP)　were　also　measured.　Results　Compared　with　HF　group,　the　body　weight,　body-fat　ratio,　Lee＇s　index,　the　serum　contents　of　TC,　TG　and　LBP　of　the　mice　from　both　MRPE-C　group　and　MRPE-H　group　were　reduced　(P＜0.05).　The　serum　HDL-C　levels　were　also　increased　by　MRPE　treatment　(P＜0.05).　Moreover,　high　dose　of　MRPE　treatment　could　significantly　reduce　the　serum　LDL-C　level　of　mice　(P＜0.05).　In　general,　a　dose-dependent　anti-obesity　effect　of　MRPE　was　observed.　Compared　with　MRPE-C　group,　body-fat　ratio　and　serum　LDL-C　level　of　the　mice　treated　with　high　dose　of　MRPE　were　reduced　by　20.43%　and　8.22%,　respectively.　In　addition,　the　anti-obesity　and　lipid　profile　modification　effect　of　high　dose　of　MRPE　was　similar　to　Monacolin　K.　Conclusion　MRPE　can　alleviate　fat　accumulation　and　reduce　body　weights　of　high-fat　induced　obese　mice　effectively,　which　indicated　the　anti-obesity　effect　of　MRPE.　©　2019,　Editorial　Office　of　Journal　of　CIFST.　All　right　reserved.