A　predator-prey　model　interaction　under　fluctuating　water　level　with　non-selective　harvesting　is　proposed　and　studied　in　this　paper.　Sufficient　conditions　for　the　permanence　of　two　populations　and　the　extinction　of　predator　population　are　provided.　The　non-negative　equilibrium　points　are　given,　and　their　stability　is　studied　by　using　the　Jacobian　matrix.　By　constructing　a　suitable　Lyapunov　function,　sufficient　conditions　that　ensure　the　global　stability　of　the　positive　equilibrium　are　obtained.　The　bionomic　equilibrium　and　the　optimal　harvesting　policy　are　also　presented.　Numerical　simulations　are　carried　out　to　show　the　feasibility　of　the　main　results.　©　2020　Na　Zhang　et　al.,　published　by　De　Gruyter　2020.