Dissolved　iron　exerts　significant　effects　on　mineral　leaching,　impurity　removal,　and　solution　purification　in　the　zinc　hydrometallurgy　process.　To　date,　iron　oxidation　and　migration　behaviors　are　yet　to　be　fully　understood　and　further　research　on　effective　regulation　mechanisms　of　iron　is　required.　In　this　paper,　zinc　sulfide　concentrate　was　used　as　the　research　object.　The　behaviors　of　both　Zn　and　Fe　during　pressure　leaching　were　investigated　for　varying　temperature,　acid　addition,　and　leaching　time.　At　temperature　of　100~160　°C,　H2SO4/Zn　ratio　of　0.9:1–1.25:1,　and　leaching　time　of　0.5–2.5　h,　the　zinc　extraction　increased　with　temperature,　acidity　and　leaching　time.　The　iron　extraction,　however,　varied　differently　with　increasing　temperature,　acidity　and　leaching　time:　(A)　it　increased　with　temperature　to　150　°C　and　then　decreased　at　higher　temperature,　and　(B)　displayed　an　initial　increase　followed　by　a　decrease　with　respect　to　the　leaching　time.　Based　on　the　characteristics　of　the　residue　phase,　chemical　phase　analysis　was　used　to　analyze　the　residue　in　detail.　The　extent　of　dissolution　of　iron-containing　minerals　and　the　extent　of　precipitation　of　ferric　ions　during　the　leaching　process　were　quantitatively　calculated.　©　2020　by　the　authors.　Licensee　MDPI,　Basel,　Switzerland.