RBC Membrane Camouflaged Semiconducting Polymer Nanoparticles for Near-Infrared Photoacoustic Imaging and Photothermal Therapy - Details

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Abstract:　Semiconducting　conjugated　polymer　nanoparticles　(SPNs)　represent　an　emerging　class　of　phototheranostic　materials　with　great　promise　for　cancer　treatment.　In　this　report,　low-bandgap　electron　donor–acceptor　(D–A)-conjugated　SPNs　with　surface　cloaked　by　red　blood　cell　membrane　(RBCM)　are　developed　for　highly　effective　photoacoustic　imaging　and　photothermal　therapy.　The　resulting　RBCM-coated　SPN　(SPN@RBCM)　displays　remarkable　near-infrared　light　absorption　and　good　photostability,　as　well　as　high　photothermal　conversion　efficiency　for　photoacoustic　imaging　and　photothermal　therapy.　Particularly,　due　to　the　small　size　(＜　5 nm),　SPN@RBCM　has　the　advantages　of　deep　tumor　penetration　and　rapid　clearance　from　the　body　with　no　appreciable　toxicity.　The　RBCM　endows　the　SPNs　with　prolonged　systematic　circulation　time,　less　reticuloendothelial　system　uptake　and　reduced　immune-recognition,　hence　improving　tumor　accumulation　after　intravenous　injection,　which　provides　strong　photoacoustic　signals　and　exerts　excellent　photothermal　therapeutic　effects.　Thus,　this　work　provides　a　valuable　paradigm　for　safe　and　highly　efficient　tumor　photoacoustic　imaging　and　photothermal　therapy　for　further　clinical　translation.[Figure　not　available:　see　fulltext.]　©　2020,　©　2020,　The　Author(s).

Keyword：

Deep tumor penetration; Photoacoustic imaging; Photothermal therapy; Red blood cell membrane camouflage; Semiconducting conjugated polymer nanoparticles

Community：

[ 1 ] [Zheng, D.]School of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou, 350002, China
[ 2 ] [Zheng, D.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 3 ] [Zheng, D.]Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, 350002, China
[ 4 ] [Yu, P.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 5 ] [Yu, P.]Mengchao Med-X Center, Fuzhou University, Fuzhou, 350116, China
[ 6 ] [Wei, Z.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 7 ] [Wei, Z.]Mengchao Med-X Center, Fuzhou University, Fuzhou, 350116, China
[ 8 ] [Zhong, C.]Department of Chemistry, Hubei Key Lab on Organic and Polymeric Optoelectronic Materials, Wuhan University, Wuhan, 430072, China
[ 9 ] [Wu, M.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 10 ] [Wu, M.]Mengchao Med-X Center, Fuzhou University, Fuzhou, 350116, China
[ 11 ] [Liu, X.]School of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou, 350002, China
[ 12 ] [Liu, X.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 13 ] [Liu, X.]Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, 350002, China
[ 14 ] [Liu, X.]Mengchao Med-X Center, Fuzhou University, Fuzhou, 350116, China

Reprint 's Address：

[Liu, X.]Mengchao Med-X Center, Fuzhou UniversityChina

Email：

xiaoloong.liu@gmail.com

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Source ：

Nano-Micro Letters

ISSN： 2311-6706

Year： 2020

Issue： 1

Volume： 12

1 6 . 4 1 9

JCR@2020

3 1 . 6 0 0

JCR@2023

ESI HC Threshold：196

JCR Journal Grade：1

CAS Journal Grade：1

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ESI Highly Cited Papers on the List： 0 Unfold All

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30 Days PV： 0

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