Fuel　cells　hold　great　potential　of　replacing　traditional　fossil　fuel　to　alleviate　the　energy　crisis　and　increasing　environmental　concerns.　Although　great　progresses　have　been　achieved　over　decades,　the　sluggish　reaction　kinetics　and　poor　durability　of　electrocatalysts　in　fuel　cells　have　been　the　decisive　bottleneck　that　limited　their　practical　applications.　Herein,　we　focus　on　the　design　and　development　of　cost-efficient　anode　electrocatalysts　for　fuel　cells　and　report　the　successful　creation　of　an　advanced　class　of　N-doped　graphene　(NG)　supported　binary　PdAg　nanocapsules　(PdAg　NCPs).　The　well-defined　nanocatalysts　with　highly　open　structure　exhibit　greatly　improved　electrocatalytic　performances　for　ethylene　glycol　oxidation　reaction　(EGOR).　In　particular,　the　optimized　PdAg　NCPs/NG　show　the　mass　and　specific　activities　of　6118.3　mA　mg−1　and　13.8　mA　cm−2,　which　are　5.8　and　6.9　times　larger　than　those　of　the　commercial　Pd/C　catalysts,　respectively.　More　importantly,　such　PdAg　NCPs/NG　can　also　maintain　at　least　500　potential　cycles　with　limited　catalytic　activity　attenuation,　showing　an　advanced　class　of　electrocatalysts　for　fuel　cells.　©　2018　Elsevier　Inc.