In　order　to　obtain　the　reasonable　operating　conditions　and　minimize　the　power　consumption　in　the　stirred　bioreactor,　the　hydrodynamic　experiments　in　the　stirred　bioreactor　have　been　taken　to　obtain　the　basic　data.　Subsequently,　an　Eulerian　model　for　the　gas–liquid–solid　three　phase　flow　in　the　stirred　bioreactor　has　been　proposed　and　the　CFD　simulation　has　been　conducted.　By　comparing　the　results　of　experiment　and　simulation,　it　can　be　concluded　that　the　simulation　results　were　consistent　with　the　experimental　data.　The　inner　relationship　between　operating　variables　and　indicators　could　be　obtained　by　comparing　the　results　of　just　suspension　speed,　gas　holdup,　power　consumption　and　operational　maps,　further　the　reasonable　operating　conditions　could　be　also　determined　under　the　minimum　power　consumption.　The　operational　maps　could　provide　the　theoretical　foundation　for　industrial　application　of　the　gas–liquid–solid　stirred　bioreactors　under　the　low　solid　concentration　(no　more　than　20　wt%).　©　2018　Elsevier　B.V.