Wound　dressing,　primarily　used　to　protect　skin　lesions,　has　recently　evolved　into　advanced　biomaterial-based　membranes　that　support　or　induce　skin　regeneration.　Here,　we　fabricated　a　chitosan/aloe　film　that　provides　a　sustaining　release　of　curcumin　for　promoting　wound　healing　and　skin　regeneration.　Uniform　embedding　of　curcumin-encapsulated　poly(lactic-co-glycolic　acid)　microspheres　in　the　chitosan/aloe　membrane　were　achieved　with　a　high-power　ultrasonic　emulsification　and　a　tape-casting　process.　The　micro-structural,　physicochemical　and　mechanical　properties　of　the　composite　film　were　examined　by　SEM,　XRD,　ATR-FTIR　and　tensile　tests.　The　biocompatibility　of　the　composite　film　was　tested　with　NIH-3T3　cells　culture　in　vitro.　Then　the　composite　film　is　implanted　in　a　full-thickness　skin　wound　model　in　Wistar　rats.　The　implantation　of　curcumin-releasing　film　led　to　the　accelerated　would　healing　and　promoted　skin　tissue　regeneration　as　compared　to　the　untreated　control　and　the　film　without　curcumin.　In　addition,　sustain-released　curcumin　likely　shows　effect　on　restraining　inflammation　and　cicatrices.　Our　findings　demonstrate　that　the　chitosan/aloe　film　with　controlled　delivery　of　curcumin　promotes　the　intrinsic　regeneration　of　skin　tissues.　©　2018　Elsevier　B.V.