Near-Infrared Light Activated Thermosensitive Ion Channel to Remotely Control Transgene System for Thrombolysis Therapy - Details

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Abstract：

Current　antithrombotic　therapeutic　strategies　often　suffer　from　severe　post-thrombotic　syndromes　(PTS),　inconvenient　daily　subcutaneous　injections　for　a　long　time　and　short　circulation　times　accompanied　by　a　dose-dependent　risk　of　intracranial　hemorrhage.　Aiming　at　noninvasive,　on-demand,　and　sustained　antithrombotic　therapy,　a　new　thrombolysis　approach　based　on　the　transgene　system　has　been　developed　to　remotely　and　precisely　control　the　expression　of　urokinase　plasminogen　activator　(uPA)　by　bioengineered　cells　for　antithrombotic　therapy　both　in　vitro　and　in　vivo.　In　this　design,　the　near-infrared　(NIR)　light　could　activate　the　expression　of　the　thermosensitive　TRPV1　channel　in　response　to　photothermal　responsive　nanotransducers　to　trigger　the　synthetic　signaling　pathway　to　secret　uPA.　By　encapsulating　bioengineered　cells　in　injectable　hydrogel　to　ensure　long-term　survival　and　convenience　for　injection,　the　engineered　cells　could　noninvasively　and　precisely　control　the　production　of　uPA　protein　in　situ　via　an　NIR　laser　to　significantly　enhance　the　thrombolysis　therapeutic　effects　by　spatiotemporally　controlling　the　local　temperature,　in　both　the　microfluidic　blood　circulation　mimic　and　the　murine　tail　thrombus　model.　This　novel　thrombolysis　approach　could　overcome　some　key　limitations　that　are　associated　with　conventional　antithrombotic　therapy,　thus　opening　a　new　direction　for　developing　remotely　and　precisely　controllable　continuous　thrombolysis　through　artificially　designed　signaling.　©　2019　WILEY-VCH　Verlag　GmbH　&　Co.　KGaA,　Weinheim

Keyword：

antithrombotic therapy; near-infrared light; thermosensitive ion channels; transgene systems; urokinase plasminogen activators

Community：

[ 1 ] [Zhang, D.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350116, China
[ 2 ] [Zhang, D.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 3 ] [Zhang, C.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 4 ] [Lan, S.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 5 ] [Huang, Y.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 6 ] [Liu, J.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 7 ] [Li, J.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350116, China
[ 8 ] [Li, J.]Institute of Molecular Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200240, China
[ 9 ] [Liu, X.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 10 ] [Yang, H.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350116, China

Reprint 's Address：

[Li, J.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou UniversityChina

Email：

lijuan@fzu.edu.cn

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ISSN： 1613-6810

Year： 2019

Issue： 27

Volume： 15

1 1 . 4 5 9

JCR@2019

1 3 . 0 0 0

JCR@2023

ESI HC Threshold：236

JCR Journal Grade：1

CAS Journal Grade：1

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SCOPUS Cited Count：

ESI Highly Cited Papers on the List： 0 Unfold All

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Chinese Cited Count：

30 Days PV： 0

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